Drugs Contraindicated in Pregnancy

DRUGS CONTRAINDICATED IN PREGNANCY
This chart represents information on select drugs that are contraindicated in women who are pregnant. Drugs that are contraindicated at a certain phase of pregnancy are noted.
Generic	Brand	Contraindicated Trimester
ANDROGENS
methyltestosterone	—	All
testosterone¹	Androderm, Androgel, Fortesta, Testim	All
testosterone cypionate	Depo-testosterone	All
testosterone enanthate	Xyosted	All
ANTI-INFECTIVES
griseofulvin	Gris-Peg	All
metronidazole	Flagyl	1st trimester for trichomoniasis
nitrofurantoin	Macrobid, Macrodantin	Pregnancy at term (38-42wks)
ribavirin	Virazole	All
sulfadiazine	—	Pregnancy at term
sulfamethoxazole/trimethoprim	Bactrim	Advise patients of the potential risk of embryo-fetal toxicity
tinidazole	Tindamax	1st trimester
CARDIOVASCULAR AGENTS
ambrisentan	Letairis	All
amlodipine/atorvastatin	Caduet	All
atorvastatin	Lipitor	All
bosentan	Tracleer	All
dipyridamole/aspirin	—	3rd trimester
dronedarone	Multaq	All
ezetimibe/simvastatin	Vytorin	All
fluvastatin	Lescol XL	All
lovastatin	Altoprev	All
pitavastatin	Livalo	All
pravastatin	—	All
rosuvastatin	Crestor	All
simvastatin	Zocor	All
warfarin²	—	All
DERMATOLOGIC AGENTS
acitretin	—	All
diclofenac sodium (topical)	—	Late pregnancy (≥30wks)⁴
finasteride	Propecia	All
isotretinoin	Absorica, Claravis	All
silver sulfadiazine	Silvadene	Late pregnancy
tazarotene	Avage, Tazorac	All
OB/GYN
ALL ORAL CONTRACEPTIVES		All
ALL HORMONE REPLACEMENT THERAPIES		All
cetrorelix	Cetrotide	All
choriogonadotropin alfa	Ovidrel	All
clomiphene	—	All
follitropin alfa	Gonal-F	All
follitropin beta	Follistim	All
ganirelix acetate	—	All
goserelin	Zoladex³	All
leuprolide acetate	Lupron Depot	All
medroxyprogeterone acetate	Depo-SubQ Provera	All
menotropins	Menopur	All
methylergonovine	Methergine	All
mifepristone	Mifeprex	All
nafarelin acetate	Synarel	All
ONCOLOGY AGENTS
abiraterone acetate	Zytiga¹	All
bexarotene	Targretin	All
bicalutamide	Casodex¹	All
degarelix	Firmagon	Advise patients of the potential risk of embryo-fetal toxicity
fluorouracil	Efudex	All
lenalidomide	Revlimid	All
leuprolide acetate	Eligard	Advise patients of the potential risk of embryo-fetal toxicity
methotrexate	Trexall, Rasuvo	All
raloxifene	Evista	All
thalidomide	Thalomid	All
triptorelin pamoate	Trelstar	Advise patients of the potential risk of embryo-fetal toxicity
PAIN MANAGEMENT
acetaminophen/aspirin/caffeine	Excedrin Migraine	Late pregnancy (≥30wks)⁴
aspirin	Bayer, Ecotrin, Durlaza	Late pregnancy (≥30wks)⁴
aspirin/caffeine/salicylamide	BC Original Formula, BC Arthritis Strength	Late pregnancy (≥30wks)⁴
butalbital/aspirin/caffeine	Fiorinal	Late pregnancy (≥30wks)⁴
butalbital/aspirin/caffeine/codeine	—	Late pregnancy (≥30wks)⁴
carisoprodol/aspirin/codeine	—	Late pregnancy (≥30wks)⁴
celecoxib	Celebrex	Late pregnancy (≥30wks)⁴
choline magnesium trisalicylate	—	Pregnancy at term
diclofenac potassium	Zipsor	Late pregnancy (≥30wks)⁴
diclofenac sodium/misoprostol	Arthrotec	All
diflunisal	—	Late pregnancy (≥30wks)⁴
dihydroergotamine mesylate	Trudhesa, Migranal	All
ergotamine tartrate/caffeine	—	All
etodolac	—	Late pregnancy (≥30wks)⁴
fenoprofen calcium	Nalfon	Late pregnancy (≥30wks)⁴
flurbiprofen	—	Late pregnancy (≥30wks)
hydrocodone bitartrate/ibuprofen	—	Late pregnancy (≥30wks)
ibuprofen	Advil, Caldolor, Motrin	Late pregnancy (≥30wks)⁴
ibuprofen/famotidine	Duexis	Late pregnancy (≥30wks)⁴
ketoprofen	—	Late pregnancy (≥30wks)⁴
ketorolac	—	Late pregnancy (≥30wks)⁴
mefenamic acid	Ponstel	Late pregnancy (≥30wks)⁴
meloxicam	Mobic	Late pregnancy (≥30wks)⁴
nabumetone	—	Late pregnancy (≥30wks)⁴
naproxen sodium	Aleve, Naprelan	Late pregnancy (≥30wks)⁴
naproxen/esomeprazole	Vimovo	Late pregnancy (≥30wks)⁴
oxaprozin	Daypro	Late pregnancy (≥30wks)⁴
piroxicam	Feldene	Late pregnancy (≥30wks)⁴
salsalate	—	Late pregnancy
PSYCHOTROPIC AGENTS
estazolam	—	All
flurazepam	—	All
hydroxyzine	Vistaril	Early pregnancy
temazepam	Restoril	All
OTHERS
acetohydroxamic acid	Lithostat	All
benzphetamine	—	All
denosumab	Prolia	All
dutasteride HCl	Avodart¹	All
dutasteride/tamsulosin HCl	Jalyn¹	All
finasteride	Proscar¹	All
histrelin acetate	Supprelin LA	All
leflunomide	Arava	All
megestrol acetate	Megace ES	All
miglustat	Zavesca	Advise patients of the potential risk of embryo-fetal toxicity
misoprostol	Cytotec	All
orlistat	Xenical	All
probenecid/colchicine	—	All
tesamorelin	Egrifta	All
NOTES
¹ Women of reproductive potential should also avoid handling capsules or crushed/broken tablets, or any skin contact with application sites. ² Contraindicated in pregnancy except in pregnant women with mechanical heart valves, who are at high risk of thromboembolism, and for whom the benefits of therapy may outweigh the risks. ³ Contraindicated in pregnancy unless used for palliative treatment of advanced breast cancer. ⁴ If needed between 20-30wks gestation, use lowest effective dose and shortest duration; monitor. Not an inclusive list of medications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. (Rev. 2/2024)

Want to read more?