Oxytrol

— THERAPEUTIC CATEGORIES —
  • Overactive bladder/enuresis

Oxytrol Generic Name & Formulations

General Description

Oxybutynin 3.9mg/day; transdermal patch.

Pharmacological Class

Antispasmodic/anticholinergic.

How Supplied

Patches—8

Manufacturer

Oxytrol Indications

Indications

Overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

Oxytrol Dosage and Administration

Adult

Apply to clean, dry area on the abdomen, hip, or buttock. 1 patch twice weekly (every 3–4 days). Rotate application sites.

Children

Not established.

Oxytrol Contraindications

Contraindications

Urinary or gastric retention, uncontrolled narrow-angle glaucoma; or patients at risk for these.

Oxytrol Boxed Warnings

Not Applicable

Oxytrol Warnings/Precautions

Warnings/Precautions

Bladder outflow or GI obstruction. Hepatic or renal impairment. Ulcerative colitis. Intestinal atony. Hiatus hernia/GERD. Discontinue if skin hypersensitivity or angioedema develops; consider discontinuing if anticholinergic CNS effects occur. Avoid in myasthenia gravis; discontinue if symptoms occur. Exposure to high environmental temperature. Pregnancy. Nursing mothers.

Oxytrol Pharmacokinetics

Metabolism

Hepatic (CYP3A4). >97% serum protein bound.

Elimination

Half-life: ~2 hours.

Oxytrol Interactions

Interactions

CNS depression potentiated by alcohol, other CNS depressants. Additive effects with other anticholinergics. May affect GI absorption of other drugs. Caution with drugs that cause or exacerbate esophagitis (eg, bisphosphonates).

Oxytrol Adverse Reactions

Adverse Reactions

Local reactions, anticholinergic effects (eg, dry mouth, constipation, dizziness, abnormal vision, somnolence, confusion, hallucinations), headache, diarrhea, rash.

Oxytrol Clinical Trials

See Literature

Oxytrol Note

Not Applicable

Oxytrol Patient Counseling

See Literature