Metadate Cd

— THERAPEUTIC CATEGORIES —
  • ADHD

Metadate Cd Generic Name & Formulations

General Description

Methylphenidate HCl 10mg, 20mg, 30mg, 40mg, 50mg, 60mg; ext-rel caps (contains immediate-release + ext-rel beads); contains sucrose.

Pharmacological Class

CNS stimulant.

How Supplied

CD—100

Manufacturer

Generic Availability

YES

Mechanism of Action

The mechanism of action of methylphenidate in ADHD is unknown. It is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space.

Metadate Cd Indications

Indications

Attention deficit hyperactivity disorder.

Metadate Cd Dosage and Administration

Adults and Children

<6yrs: not established. Take before breakfast. Swallow whole or sprinkle contents onto applesauce (swallow immediately); do not crush, chew, or divide beads. ≥6yrs: initially 20mg once daily, may increase weekly by 10–20mg/day; max 60mg once daily.

Metadate Cd Contraindications

Contraindications

During or within 14 days of MAOIs. Hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency.

Metadate Cd Boxed Warnings

Boxed Warning

Abuse, misuse, and addiction.

Metadate Cd Warnings/Precautions

Warnings/Precautions

High potential for abuse, misuse, and addiction; assess patient’s risk before prescribing. Assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, or other cardiac disease. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors of developing a manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Risk for acute angle glaucoma. History of increased IOP or open angle glaucoma; monitor closely. Assess family history and evaluate for tics or Tourette’s syndrome before initiating; monitor for emergence or worsening, and discontinue if clinically appropriate. Peripheral vasculopathy, including Raynaud's Phenomenon; monitor for digital changes. Monitor BP, HR, growth in children. Reduce dose or discontinue if paradoxical aggravation of symptoms occur. Reevaluate periodically. Pregnancy. Nursing mothers: monitor infants.

Metadate Cd Pharmacokinetics

Absorption

Median time to maximum concentration showed 2 phases: ~1.5 hours (Tmax1); ~4.5 hours (Tmax2).

Distribution

Plasma protein bound: 10–33%. Volume of distribution: 2.65 ± 1.11 L/kg (d-methylphenidate) and 1.80 ± 0.91 L/kg (l-methylphenidate).

Metabolism

Primarily by de-esterification to α-phenyl-piperidine acetic acid (PPAA).

Elimination

Renal (90%). Half-life: 6.8 hours.

Metadate Cd Interactions

Interactions

See Contraindications. Hypertensive crisis with MAOIs. Avoid alcohol. May decrease effectiveness of antihypertensive drugs; monitor and adjust dose of antihypertensives as needed. Concomitant halogenated anesthetics may increase the risk of sudden BP and HR increase during surgery; avoid use. Concomitant risperidone may increase risk of extrapyramidal symptoms; monitor.

Metadate Cd Adverse Reactions

Adverse Reactions

Headache, anorexia, abdominal pain, insomnia; priapism, hypertension, tachycardia, visual disturbances, glaucoma, motor/verbal tics.

Metadate Cd Clinical Trials

See Literature

Metadate Cd Note

Not Applicable

Metadate Cd Patient Counseling

See Literature