Metadate Cd Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Metadate Cd Indications
Indications
Metadate Cd Dosage and Administration
Adults and Children
Metadate Cd Contraindications
Contraindications
Metadate Cd Boxed Warnings
Boxed Warning
Abuse, misuse, and addiction.
Metadate Cd Warnings/Precautions
Warnings/Precautions
High potential for abuse, misuse, and addiction; assess patient’s risk before prescribing. Assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, or other cardiac disease. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors of developing a manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Risk for acute angle glaucoma. History of increased IOP or open angle glaucoma; monitor closely. Assess family history and evaluate for tics or Tourette’s syndrome before initiating; monitor for emergence or worsening, and discontinue if clinically appropriate. Peripheral vasculopathy, including Raynaud's Phenomenon; monitor for digital changes. Monitor BP, HR, growth in children. Reduce dose or discontinue if paradoxical aggravation of symptoms occur. Reevaluate periodically. Pregnancy. Nursing mothers: monitor infants.
Metadate Cd Pharmacokinetics
Absorption
Median time to maximum concentration showed 2 phases: ~1.5 hours (Tmax1); ~4.5 hours (Tmax2).
Distribution
Plasma protein bound: 10–33%. Volume of distribution: 2.65 ± 1.11 L/kg (d-methylphenidate) and 1.80 ± 0.91 L/kg (l-methylphenidate).
Elimination
Metadate Cd Interactions
Interactions
See Contraindications. Hypertensive crisis with MAOIs. Avoid alcohol. May decrease effectiveness of antihypertensive drugs; monitor and adjust dose of antihypertensives as needed. Concomitant halogenated anesthetics may increase the risk of sudden BP and HR increase during surgery; avoid use. Concomitant risperidone may increase risk of extrapyramidal symptoms; monitor.
Metadate Cd Adverse Reactions
Adverse Reactions
Headache, anorexia, abdominal pain, insomnia; priapism, hypertension, tachycardia, visual disturbances, glaucoma, motor/verbal tics.
Metadate Cd Clinical Trials
See Literature
Metadate Cd Note
Not Applicable
Metadate Cd Patient Counseling
See Literature