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Disulfiram Generic Name & Formulations
Legal Class
Rx
General Description
Disulfiram 250mg, 500mg; tabs.
Pharmacological Class
Alcohol deterrent.
How Supplied
Contact supplier
Manufacturer
Disulfiram Indications
Indications
Adjunct in management of chronic alcoholic patients who want to remain sober.
Disulfiram Dosage and Administration
Adult
Abstain for at least 12hrs. Initially 500mg once daily for 1–2 weeks then 250mg once daily; max 500mg daily. Continue until patient develops basis for self-control.
Children
Not established.
Disulfiram Contraindications
Contraindications
Severe cardiovascular disease. Psychosis. Allergy to thiuram in pesticides and rubber. Concomitant metronidazole, paraldehyde, alcohol-containing products.
Disulfiram Boxed Warnings
Not Applicable
Disulfiram Warnings/Precautions
Warnings/Precautions
Never administer when in a state of alcohol intoxication. Advise family members of alcohol effect. Diabetes. Hypothyroidism. Epilepsy. Cerebral damage. Nephritis. Hepatic cirrhosis or insufficiency. Ethylene dibromide inhalation. Monitor hepatic function, electrolytes, blood, CBCs. Alcohol trial in patients >50yrs: not recommended. Pregnancy. Nursing mothers.
Disulfiram Pharmacokinetics
See Literature
Disulfiram Interactions
Interactions
See Contraindications. Alcohol-like reaction to metronidazole, paraldehyde, alcohol-containing drugs and elixirs, some so-called alcohol-free beverages, tonics, foods, aftershave, back rubs. Potentiates phenytoin, oral anticoagulants, isoniazid.
Disulfiram Adverse Reactions
Adverse Reactions
Optic, peripheral and polyneuritis; peripheral neuropathy, drowsiness, rash, psychosis, hepatitis.
Disulfiram Clinical Trials
See Literature
Disulfiram Note
Notes
Formerly known under the brand name Antabuse.
Disulfiram Patient Counseling
See Literature
