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Metaxalone Generic Name & Formulations
Legal Class
Rx
General Description
Metaxalone 400mg, 800mg+; tabs; +scored.
Pharmacological Class
Muscle relaxant (central).
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system (CNS) depression. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber.
Metaxalone Indications
Indications
As adjunct treatment for acute, painful musculoskeletal conditions.
Metaxalone Dosage and Administration
Adult
800mg 3–4 times daily.
Children
≤12yrs: not established.
Metaxalone Contraindications
Contraindications
Anemias. Significant renal or hepatic dysfunction.
Metaxalone Boxed Warnings
Not Applicable
Metaxalone Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment (monitor LFTs). Elderly. Pregnancy, nursing mothers: not recommended.
Metaxalone Pharmacokinetics
Absorption
Peak plasma concentrations: ~3 hours (after a 400 mg dose).
Distribution
Volume of distribution: ~800 L.
Elimination
Renal. Half-life: 9.0 ± 4.8 hours.
Metaxalone Interactions
Interactions
Increased risk of sedation, respiratory depression with concomitant other CNS depressants (eg, alcohol, benzodiazepines, opioids, TCAs); monitor closely. Risk of serotonin syndrome with serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, 5-HT3 antagonists, opioids, mirtazapine, trazodone, tramadol, MAOIs, linezolid, IV methylene blue); monitor and discontinue if suspected. Concomitant with food may enhance CNS depression. May cause false (+) Benedict's test.
Metaxalone Adverse Reactions
Adverse Reactions
Drowsiness, dizziness, headache, nervousness, GI upset, rash, jaundice, hemolytic anemia, leukopenia; hypersensitivity reactions.
Metaxalone Clinical Trials
See Literature
Metaxalone Note
Notes
Formerly known under the brand name Skelaxin.
Metaxalone Patient Counseling
See Literature
