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Pentostatin Generic Name & Formulations
Legal Class
Rx
General Description
Pentostatin 10mg/vial; lyophilized pwd for IV inj after reconstitution; contains mannitol.
Pharmacological Class
Antimetabolite.
How Supplied
Single-dose vials—1
Manufacturer
Pentostatin Indications
Indications
Active hairy cell leukemia.
Pentostatin Dosage and Administration
Adult
Ensure adequate hydration. Give as IV bolus or infuse over 20–30 minutes after dilution. 4mg/m2 every other week. Reevaluate after 6 months; discontinue if complete or partial response not achieved; max duration of therapy 12 months. Withhold dose if ANC <200 cells/mm3; may resume when resolved.
Children
Not recommended.
Pentostatin Contraindications
Not Applicable
Pentostatin Boxed Warnings
Not Applicable
Pentostatin Warnings/Precautions
Warnings/Precautions
Active infections; treat prior to initiating therapy. Withhold or discontinue therapy if severe rash or neurotoxicity develops. Renal impairment. Monitor and obtain CBCs, liver, and renal function before and during therapy. Pregnancy (Cat. D); avoid use. Nursing mothers: not recommended.
Pentostatin Pharmacokinetics
See Literature
Pentostatin Interactions
Interactions
Concomitant fludarabine: not recommended. Potentiates vidarabine. Acute pulmonary toxicity and hypotension with carmustine, etoposide, and high dose cyclophosphamide (see literature).
Pentostatin Adverse Reactions
Adverse Reactions
GI upset, fever, rash, fatigue, leukopenia, pruritus, cough, myalgia, chills, headache, abdominal pain, anorexia, asthenia, stomatitis, rhinitis, dyspnea, anemia, pain, sweating, infections, thrombocytopenia.
Pentostatin Clinical Trials
See Literature
Pentostatin Note
Not Applicable
Pentostatin Patient Counseling
See Literature
