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Trihexyphenidyl Generic Name & Formulations
Legal Class
Rx
General Description
Trihexyphenidyl HCl 2mg, 5mg; scored tabs.
Pharmacological Class
Anticholinergic.
See Also
How Supplied
Contact supplier.
Manufacturer
Trihexyphenidyl Indications
Indications
Adjunct in Parkinsonism. Drug-induced extrapyramidal symptoms (EPS).
Trihexyphenidyl Dosage and Administration
Adult
Take with food. Give in 3–4 divided doses. Parkinsonism: 1mg on day 1, may increase by 2mg every 3–5 days; usual max 6–15mg/day. Concomitant levodopa: 3–6mg/day and reduce levodopa dose. EPS: 1mg on day 1; range 5–15mg/day.
Children
Not recommended.
Trihexyphenidyl Contraindications
Contraindications
Tardive dyskinesia. Narrow-angle glaucoma.
Trihexyphenidyl Boxed Warnings
Not Applicable
Trihexyphenidyl Warnings/Precautions
Warnings/Precautions
Cardiovascular, renal, or hepatic disorders. Hypertension. Psychosis. GI or GU obstruction. Exposure to extreme heat. Monitor intraocular pressure. Avoid abrupt cessation. Nursing mothers.
Trihexyphenidyl Pharmacokinetics
See Literature
Trihexyphenidyl Interactions
Interactions
Potentiates CNS depression with alcohol, CNS depressants. Antagonizes psychotropics. Additive anticholinergic effects with MAOIs. Paralytic ileus with phenothiazines, tricyclic antidepressants.
Trihexyphenidyl Adverse Reactions
Adverse Reactions
Anticholinergic and antihistaminic effects, confusion, anhidrosis, excitement, nausea, vomiting, angle-closure glaucoma, hallucinations, neuroleptic malignant syndrome, heat stroke, drowsiness.
Trihexyphenidyl Clinical Trials
See Literature
Trihexyphenidyl Note
Notes
Formerly known under the brand name Artane.
Trihexyphenidyl Patient Counseling
See Literature
