Acetylcysteine Solution For Inhalation

See literature for administration of aerosol. Nebulization-face mask, mouth piece, tracheostomy: 1–10mL of 20% soln or 2–20mL of 10% soln every 2–6 hours; usual dose: 3–5mL of 20% soln or 6–10mL of 10% soln 3–4 times daily. Nebulization tent, croupette: individualize; requires very large volumes, occasionally as much as 300mL during a single treatment period; recommended dose is the volume of acetylcysteine (using 10% or 20%) that will maintain a very heavy mist for the desired period. Direct instillation: 1–2mL of 10% to 20% soln may be given as often as every hour. Tracheostomy: 1–2mL of 10% or 20% soln every 1–4 hours by instillation into the tracheostomy. Direct instillation into segment of bronchopulmonary tree: Under local anesthesia and direct vision, insert small plastic catheter into trachea; 2–5mL of 20% soln may be instilled by means of syringe connected to catheter. Percutaneous intrathecal catheter: 1–2mL of 20% soln or 2–4mL of 10% soln every 1–4 hours given by syringe attached to catheter. Diagnostic bronchograms: Two or three administrations of 1–2mL of 20% soln or 2–4mL of 10% soln should be given by nebulization or by instillation intratracheally, prior to procedure.