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Dantrium Generic Name & Formulations
Legal Class
Rx
General Description
Dantrolene sodium 25mg, 50mg, 100mg; caps.
Pharmacological Class
Muscle relaxant (local).
How Supplied
Caps—100
Manufacturer
Generic Availability
YES
Dantrium Indications
Indications
Chronic spasticity due to upper motor neuron disorders (eg, spinal cord injury, stroke, cerebral palsy, multiple sclerosis).
Dantrium Dosage and Administration
Adult
Use lowest effective dose. 25mg once daily for 7 days, then 25mg 3 times daily for 7 days, then 50mg 3 times daily for 7 days, then 100mg 3 times daily; max 100mg 4 times daily.
Children
<5yrs: not established. ≥5yrs: Use lowest effective dose. 0.5mg/kg once daily for 7 days, then 0.5mg/kg 3 times daily for 7 days, then 1mg/kg 3 times daily for 7 days, then 2mg/kg 3 times daily; max 100mg 4 times daily.
Dantrium Contraindications
Contraindications
Active hepatic disease. Spasticity utilization to sustain upright posture/balance in locomotion or to obtain increased function.
Dantrium Boxed Warnings
Boxed Warning
Hepatotoxicity.
Dantrium Warnings/Precautions
Warnings/Precautions
Risk of hepatotoxicity (esp. females or patients >35 years, or concomitant other drugs); monitor liver function at baseline and during therapy; discontinue if hepatitis or liver abnormalities develop. History of liver disease. Pulmonary dysfunction. Severely impaired cardiac function. Discontinue if no improvement after 45 days of treatment. Avoid exposure to sunlight. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Dantrium Pharmacokinetics
See Literature
Dantrium Interactions
Interactions
Estrogens may increase risk of hepatotoxicity. Potentiates CNS depressants (eg, sedatives, tranquilizers). Avoid concurrent verapamil (cardiovascular collapse). May potentiate vecuronium.
Dantrium Adverse Reactions
Adverse Reactions
Drowsiness, dizziness, weakness, fatigue, diarrhea, urinary changes, tachycardia, seizures, depression; hepatotoxicity, hepatitis, photosensitivity, pleural effusion with associated eosinophilia.
Dantrium Clinical Trials
See Literature
Dantrium Note
Not Applicable
Dantrium Patient Counseling
See Literature
