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Cystadane Generic Name & Formulations
Legal Class
Rx
General Description
Betaine anhydrous 1g; per scoopful; pwd for oral soln after reconstitution.
Pharmacological Class
Methylating agent.
How Supplied
Bottle—180g (w. measuring scoop)
Manufacturer
Generic Availability
YES
Cystadane Indications
Indications
Treatment of homocystinuria (eg, cystathionine beta-synthase [CBS] deficiency, 5,10-methylenetetrahydrofolate reductase [MTHFR] deficiency, cobalamin cofactor metabolism [cbl] defect) to decrease elevated homocysteine blood levels.
Cystadane Dosage and Administration
Adults and Children
Dissolve one scoop (1g betaine anhydrous pwd) in 4–6 ounces of water, juice, milk, formula, or mixed with food for immediate ingestion. <3yrs: initially 100mg/kg/day divided in twice daily doses, may increase weekly by 50mg/kg increments. ≥3yrs: 3g twice daily. Increase gradually until plasma total homocysteine is undetectable or present only in small amounts. Up to 20g/day has been used.
Cystadane Contraindications
Not Applicable
Cystadane Boxed Warnings
Not Applicable
Cystadane Warnings/Precautions
Warnings/Precautions
Hypermethioninemia. Monitor plasma methionine concentrations in patients with CBS deficiency. Pregnancy. Nursing mothers.
Cystadane Pharmacokinetics
See Literature
Cystadane Interactions
Not Applicable
Cystadane Adverse Reactions
Adverse Reactions
Nausea, GI distress; hypermethioninemia, cerebral edema.
Cystadane Clinical Trials
See Literature
Cystadane Note
Not Applicable
Cystadane Patient Counseling
See Literature
