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E.e.s. 400 Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Erythromycin (as ethylsuccinate) 400mg.
Pharmacological Class
Macrolide.
See Also
How Supplied
Granules—100mL, 200mL; Tabs—100
Manufacturer
E.e.s. 400 Tablets Indications
Indications
Treatment of susceptible infections including upper and lower respiratory, skin and skin structure, genitourinary, Legionnaires' disease, pertussis, listeriosis. Prophylaxis for rheumatic fever attacks in penicillin-allergic patients.
E.e.s. 400 Tablets Dosage and Administration
Adult
1.6g/day in 2, 3, or 4 evenly divided doses; max 4g/day. Legionnaires: 1.6–4g/day in divided doses. Prophylaxis: 400mg twice daily. See full labeling.
Children
Mild-to-moderate infections: 30–50mg/kg/day in 2, 3, or 4 evenly divided doses; may double dose in severe infections. See full labeling.
E.e.s. 400 Tablets Contraindications
Contraindications
Concomitant terfenadine, astemizole, cisapride, pimozide, ergotamine, dihydroergotamine, statins (eg, lovastatin, simvastatin).
E.e.s. 400 Tablets Boxed Warnings
Not Applicable
E.e.s. 400 Tablets Warnings/Precautions
Warnings/Precautions
Avoid in proarrhythmic conditions (eg, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia); risk of QT prolongation. Myasthenia gravis. Hepatic impairment. Elderly. Infants: risk of infantile hypertrophic pyloric stenosis; monitor for vomiting or irritability with feeding. Pregnancy (Cat.B). Nursing mothers.
E.e.s. 400 Tablets Pharmacokinetics
See Literature
E.e.s. 400 Tablets Interactions
Interactions
See Contraindications. May potentiate theophylline (reduce dose of theophylline), digoxin, oral anticoagulants, hexobarbital, phenytoin, valproate. May potentiate CYP3A substrates (eg, triazolam, midazolam, statins [rhabdomyolysis], sildenafil [reduce dose of sildenafil], colchicine [reduce starting dose of colchicine, max dose should be lowered; monitor], verapamil, amlodipine, diltiazem, carbamazepine, cyclosporine, tacrolimus, alfentanil, disopyramide, bromocriptine, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine); consider dose adjustments and monitor. May be antagonized by theophylline. Hypotension, bradyarrhythmias, lactic acidosis with verapamil. QT prolongation with concomitant Class 1A (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics; avoid. May interfere with fluorometric detection of urinary catecholamines.
E.e.s. 400 Tablets Adverse Reactions
Adverse Reactions
GI upset, abdominal pain, anorexia, hepatic dysfunction; QT prolongation, C. difficile-associated diarrhea, superinfection (discontinue if occurs).
E.e.s. 400 Tablets Clinical Trials
See Literature
E.e.s. 400 Tablets Note
Not Applicable
E.e.s. 400 Tablets Patient Counseling
See Literature
