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Ceftazidime Generic Name & Formulations
Legal Class
Rx
General Description
Ceftazidime 1g, 2g; IM or IV inj; sodium content 2.3mEq/g.
Pharmacological Class
Cephalosporin.
How Supplied
Contact supplier
Manufacturer
Mechanism of Action
Ceftazidime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Ceftazidime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
Ceftazidime Indications
Indications
Susceptible infections including septicemia, pneumonia, skin and skin structure, bone and joint, gynecologic, intraabdominal, meningitis, urinary tract.
Ceftazidime Dosage and Administration
Adult
Uncomplicated UTIs: 250mg IV or IM every 12hrs. Complicated UTIs: 500mg IV or IM every 8–12hrs. Uncomplicated pneumonia, mild skin or skin structure: 500mg–1g IV or IM every 8hrs. Bone and joint: 2g IV every 12hrs. Serious gynecologic, intraabdominal, meningitis, or very severe life-threatening (esp. immunocompromised): 2g IV every 8hrs. Lung infections by Pseudomonas in cystic fibrosis: 30–50mg/kg IV every 8hrs (max 6g/day). Renal impairment: CrCl 31–50mL/min: 1g every 12hrs; CrCl 16–30mL/min: 1g every 24hrs; CrCl 6–15mL/min: 500mg every 24hrs; CrCl <5mL/min: 500mg every 48hrs. Hemodialysis: 1g loading dose then 1g after dialysis session. Peritoneal dialysis: 1g loading dose then 500mg every 24hrs.
Children
Neonates: 30mg/kg IV every 12hrs. 1mo–12yrs: 30–50mg/kg IV every 8hrs (max 6g/day). Renal impairment: reduce dose.
Ceftazidime Contraindications
Not Applicable
Ceftazidime Boxed Warnings
Not Applicable
Ceftazidime Warnings/Precautions
Warnings/Precautions
Penicillin or other allergy. Renal impairment; see Adult. Monitor prothrombin time in renal or hepatic dysfunction, poor nutritional states, or long-term use. GI disease (esp. colitis). Pregnancy. Nursing mothers.
Ceftazidime Pharmacokinetics
Elimination
Renal. Half-life: 1.9 hours.
Ceftazidime Interactions
Interactions
May potentiate nephrotoxicity of aminoglycosides or diuretics. Antagonized by chloramphenicol. False (+) glucose test with Clinitest, Benedict's, or Fehling's soln.
Ceftazidime Adverse Reactions
Adverse Reactions
Hypersensitivity reactions (eg, rash, pruritus, fever), local reactions, GI upset, elevated liver enzymes; C. difficile-associated diarrhea.
Ceftazidime Clinical Trials
See Literature
Ceftazidime Note
Notes
Formerly known under the brand name Fortaz.
Ceftazidime Patient Counseling
See Literature
