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Artesunate For Injection Generic Name & Formulations
Legal Class
Rx
General Description
Artesunate 110mg; per vial; pwd for IV inj after reconstitution.
Pharmacological Class
Antimalarial.
How Supplied
Single-dose vial—1, 4 (w. diluent)
Manufacturer
Generic Availability
NO
Artesunate For Injection Indications
Indications
Initial treatment of severe malaria.
Limitations of Use
Not for treating the hypnozoite liver stage forms of Plasmodium and therefore not prevent relapses of malaria due to Plasmodium vivax or Plasmodium ovale.
Artesunate For Injection Dosage and Administration
Adults and Children
<6months: not established. Give by slow IV bolus inj over 1–2mins. ≥6months: 2.4mg/kg at 0hr, 12hrs, and 24hrs, and thereafter given once daily until able to tolerate oral antimalarial therapy. Complete treatment course with an appropriate oral antimalarial regimen (eg, an 8-aminoquinoline).
Artesunate For Injection Contraindications
Not Applicable
Artesunate For Injection Boxed Warnings
Not Applicable
Artesunate For Injection Warnings/Precautions
Warnings/Precautions
Monitor for post-treatment hemolytic anemia for 4 weeks. Consider discontinuation if hypersensitivity reactions occur; use alternative treatment. Pregnancy. Nursing mothers.
Artesunate For Injection Pharmacokinetics
See Literature
Artesunate For Injection Interactions
Interactions
May be potentiated by strong UGT inhibitors (eg, axitinib, vandetanib, imatinib, diclofenac); monitor. May be antagonized by ritonavir, nevirapine, or strong UGT inducers (eg, rifampin, carbamazepine, phenytoin); monitor for possible reduced efficacy if used concomitantly.
Artesunate For Injection Adverse Reactions
Adverse Reactions
Acute renal failure requiring dialysis, hemoglobinuria, jaundice, anemia, increased transaminase, thrombocytopenia, hyperbilirubinemia, leukocytosis, acute respiratory distress syndrome, lymphopenia, neutropenia.
Artesunate For Injection Clinical Trials
See Literature
Artesunate For Injection Note
Not Applicable
Artesunate For Injection Patient Counseling
See Literature
