Eloctate

Dosage Required (IU) = Body Weight (kg) × Desired % Factor VIII Increase × 0.5. Individualize. Give by IV bolus infusion at max rate 10mL/min. Children <6yrs: higher or more frequent dosing may be needed (see full labeling). Hemorrhage: Minor/moderate: obtain 40–60% FVIII increase; give 20–30 IU/kg every 24–48hrs until resolved. Major: obtain 80–100% FVIII increase; give 40–50 IU/kg every 12–24hrs until resolved ( approx. 7–10 days). Perioperative: Minor: obtain 50–80% FVIII increase; give 25–40 IU/kg every 24hrs for at least 1 day until healing achieved. Major: obtain 80–120% FVIII increase (pre- and post-op); give pre-op dose (40–60 IU/kg) followed by repeat dose (40–50 IU/kg) after 8–24hrs and then every 24hrs to maintain target range; give until adequate wound healing, then continue for at least 7 days to maintain target range. Routine prophylaxis: 50 IU/kg every 4 days; may adjust to range of 25–65 IU/kg at 3–5 day intervals based on response.