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Rectiv Generic Name & Formulations
Legal Class
Rx
General Description
Nitroglycerin 0.4% (1.5mg/inch); oint; contains lanolin.
Pharmacological Class
Nitrate.
How Supplied
Oint—30g
Manufacturer
Rectiv Indications
Indications
Treatment of moderate-to-severe pain associated with chronic anal fissure.
Rectiv Dosage and Administration
Adult
Apply using finger covering (eg, plastic-wrap, disposable surgical glove, finger cot). ≥18yrs: 1 inch of ointment intra-anally every 12 hours for up to 3 weeks. Not for oral, ophthalmic, or intravaginal use.
Children
<18yrs: not recommended.
Rectiv Contraindications
Contraindications
Concomitant PDE5 inhibitors (eg, sildenafil, vardenafil, tadalafil). Severe anemia. Increased intracranial pressure.
Rectiv Boxed Warnings
Not Applicable
Rectiv Warnings/Precautions
Warnings/Precautions
Volume depleted. Hypotension. Cardiomyopathy. CHF. Acute MI. Poor cardiac function. Elderly. Pregnancy (Cat.C). Nursing mothers.
Rectiv Pharmacokinetics
Elimination
Half-life: 2–3 minutes.
Rectiv Interactions
Interactions
See Contraindications. Hypotension with PDE5 inhibitors, antihypertensive drugs (eg, calcium channel blockers, beta-adrenergic blockers, other nitrates). Potentiated by aspirin. Antagonizes tissue-type plasminogen activator (t-PA); caution. Anticoagulant effect of heparin may be reduced; monitor APTT. Potentiates ergotamine; possible ergotism. Additive vasodilating effects with alcohol; avoid use.
Rectiv Adverse Reactions
Adverse Reactions
Headache, dizziness, hypotension (including orthostatic hypotension); rare: flushing, allergic reactions, application site reactions (eg, drug rash, exfoliative dermatitis), methemoglobinemia.
Rectiv Clinical Trials
See Literature
Rectiv Note
Not Applicable
Rectiv Patient Counseling
See Literature
