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Chirhostim Generic Name & Formulations
Legal Class
Rx
General Description
Human secretin 16mcg, 40mcg; per vial; lyophilized pwd for IV injection after reconstitution.
Pharmacological Class
Hormone.
How Supplied
Single-dose vial—1
Manufacturer
Generic Availability
NO
Chirhostim Indications
Indications
For the stimulation of pancreatic secretions, including bicarbonate to aid in the diagnosis of pancreatic exocrine dysfunction, and to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP). For the stimulation of gastrin secretin to aid in the diagnosis of gastrinoma.
Chirhostim Dosage and Administration
Adult
See full labeling. Discontinue interacting drugs (eg, anticholinergics, H2-receptor antagonists, or PPIs) prior to testing accordingly; see Interactions. Administer as IV inj over 1min. Exocrine pancreas dysfunction (fast for at least 12–15hrs prior to testing): 0.2mcg/kg. ERCP: 0.2mcg/kg. Gastrinoma (fast for at least 12hrs prior to testing): 0.4mcg/kg.
Children
Not established.
Chirhostim Contraindications
Not Applicable
Chirhostim Boxed Warnings
Not Applicable
Chirhostim Warnings/Precautions
Warnings/Precautions
Stimulation testing should only be performed by physicians with sufficient expertise. Undergone vagotomy, inflammatory bowel disease: may be hyporesponsive to stimulation. Alcoholic or other liver disease: may be hyperresponsive to stimulation. Pregnancy. Nursing mothers.
Chirhostim Pharmacokinetics
See Literature
Chirhostim Interactions
Interactions
Possible hyporesponse to stimulation testing with concomitant anticholinergics; discontinue at least 5 half-lives prior to testing. Possible hyperresponse with concomitant H2-receptor antagonists; discontinue at least 2 days prior to testing. Concomitant PPIs may cause hyperresponse to stimulation: refer to specific labeling prior to testing.
Chirhostim Adverse Reactions
Adverse Reactions
Nausea, vomiting, flushing, upset stomach.
Chirhostim Clinical Trials
See Literature
Chirhostim Note
Not Applicable
Chirhostim Patient Counseling
See Literature
