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Aczone Generic Name & Formulations
Legal Class
Rx
General Description
Dapsone 5%; gel.
Pharmacological Class
Sulfone.
See Also
How Supplied
Gel 5% (tubes)—30g, 60g, 90g; Gel 7.5% (pumps)—30g, 60g, 90g
Manufacturer
Generic Availability
NO
Mechanism of Action
The mechanism of action of dapsone gel for acne treatment is unknown.
Aczone Indications
Indications
Acne vulgaris.
Aczone Dosage and Administration
Adult
Wash skin and pat dry. Apply pea-sized amount to affected area in a thin layer twice daily in the AM & PM. Rub in gently and completely. Wash hands after use. Reevaluate if no improvement after 12 weeks.
Children
<12yrs: not recommended.
Aczone Contraindications
Not Applicable
Aczone Boxed Warnings
Not Applicable
Aczone Warnings/Precautions
Warnings/Precautions
Avoid in congenital or idiopathic methemoglobinemia. G6PD deficiency: may have increased risk of methemoglobinemia or hemolytic anemia; discontinue if occurs. Pregnancy. Nursing mothers.
Aczone Pharmacokinetics
See Literature
Aczone Interactions
Interactions
Increased risk of hemolysis in G6PD-deficient patients with concomitant trimethoprim/sulfamethoxazole, other folic acid antagonists (eg, pyrimethamine), anticonvulsants, rifampin, St. John's wort. Increased risk of methemoglobinemia with concomitant sulfonamides, acetaminophen, chloroquine, nitrates, nitrites, nitrofurantoin, phenobarbital, phenytoin, primaquine, quinine, and others. Skin/hair discoloration with topical benzoyl peroxide.
Aczone Adverse Reactions
Adverse Reactions
Application site reactions (oiliness, peeling, dryness, erythema, pruritus).
Aczone Clinical Trials
See Literature
Aczone Note
Not Applicable
Aczone Patient Counseling
See Literature
Images
