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Minocin For Injection Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline 100mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains magnesium sulfate heptahydrate.
Pharmacological Class
Tetracycline antibiotic.
See Also
How Supplied
Caps—60; Single-use vials—1, 10
Manufacturer
Minocin For Injection Indications
Indications
Adjunct in severe acne.
Minocin For Injection Dosage and Administration
Adult
Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children
≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Minocin For Injection Contraindications
Not Applicable
Minocin For Injection Boxed Warnings
Not Applicable
Minocin For Injection Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
Minocin For Injection Pharmacokinetics
See Literature
Minocin For Injection Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Minocin For Injection Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
Minocin For Injection Clinical Trials
See Literature
Minocin For Injection Note
Not Applicable
Minocin For Injection Patient Counseling
See Literature
Minocin For Injection Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline 100mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains magnesium sulfate heptahydrate.
Pharmacological Class
Tetracycline antibiotic.
See Also
How Supplied
Caps—60; Single-use vials—1, 10
Manufacturer
Minocin For Injection Indications
Indications
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax due to B. anthracis.
Minocin For Injection Dosage and Administration
Adult
Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children
≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Minocin For Injection Contraindications
Not Applicable
Minocin For Injection Boxed Warnings
Not Applicable
Minocin For Injection Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
Minocin For Injection Pharmacokinetics
See Literature
Minocin For Injection Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Minocin For Injection Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
Minocin For Injection Clinical Trials
See Literature
Minocin For Injection Note
Not Applicable
Minocin For Injection Patient Counseling
See Literature
Minocin For Injection Generic Name & Formulations
Legal Class
Rx
General Description
Minocycline 100mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains magnesium sulfate heptahydrate.
Pharmacological Class
Tetracycline antibiotic.
See Also
How Supplied
Caps—60; Single-use vials—1, 10
Manufacturer
Minocin For Injection Indications
Indications
Adjunct in acute intestinal amebiasis.
Minocin For Injection Dosage and Administration
Adult
Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Children
≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.
Minocin For Injection Contraindications
Not Applicable
Minocin For Injection Boxed Warnings
Not Applicable
Minocin For Injection Warnings/Precautions
Warnings/Precautions
Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.
Minocin For Injection Pharmacokinetics
See Literature
Minocin For Injection Interactions
Interactions
Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.
Minocin For Injection Adverse Reactions
Adverse Reactions
Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, renal toxicity, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome. IV: magnesium intoxication, inj site reactions.
Minocin For Injection Clinical Trials
See Literature
Minocin For Injection Note
Not Applicable
Minocin For Injection Patient Counseling
See Literature
