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Nitropress Generic Name & Formulations
Legal Class
Rx
General Description
Sodium nitroprusside 25mg/mL; soln for IV infusion after dilution.
Pharmacological Class
Vasodilator.
How Supplied
Single-dose vials (2mL)—100
Manufacturer
Nitropress Indications
Indications
To produce controlled hypotension to reduce surgical bleeding.
Nitropress Dosage and Administration
Adults and Children
Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min and no more than 10 minutes. Titrate infusion rate (see literature).
Nitropress Contraindications
Contraindications
Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute CHF associated with reduced peripheral vascular resistance.
Nitropress Boxed Warnings
Boxed Warning
Not suitable for direct injection. Excessive hypotension. Cyanide toxicity.
Nitropress Warnings/Precautions
Warnings/Precautions
Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); monitor acid-base disturbances and venous oxygen concentration. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Poor surgical risk. Hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nitropress Pharmacokinetics
See Literature
Nitropress Interactions
Interactions
Hypotensive effect potentiated by ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.
Nitropress Adverse Reactions
Adverse Reactions
Excessive hypotension, cyanide toxicity, methemoglobinemia, abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitch, nausea, palpitations, restlessness, rash, hypothyroidism, ileus, flushing, infusion site reactions.
Nitropress Clinical Trials
See Literature
Nitropress Note
Not Applicable
Nitropress Patient Counseling
See Literature
Nitropress Generic Name & Formulations
Legal Class
Rx
General Description
Sodium nitroprusside 25mg/mL; soln for IV infusion after dilution.
Pharmacological Class
Vasodilator.
How Supplied
Single-dose vials (2mL)—100
Manufacturer
Nitropress Indications
Indications
Acute CHF.
Nitropress Dosage and Administration
Adults and Children
Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min and no more than 10 minutes. Titrate infusion rate (see literature).
Nitropress Contraindications
Contraindications
Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute CHF associated with reduced peripheral vascular resistance.
Nitropress Boxed Warnings
Boxed Warning
Not suitable for direct injection. Excessive hypotension. Cyanide toxicity.
Nitropress Warnings/Precautions
Warnings/Precautions
Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); monitor acid-base disturbances and venous oxygen concentration. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Poor surgical risk. Hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nitropress Pharmacokinetics
See Literature
Nitropress Interactions
Interactions
Hypotensive effect potentiated by ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.
Nitropress Adverse Reactions
Adverse Reactions
Excessive hypotension, cyanide toxicity, methemoglobinemia, abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitch, nausea, palpitations, restlessness, rash, hypothyroidism, ileus, flushing, infusion site reactions.
Nitropress Clinical Trials
See Literature
Nitropress Note
Not Applicable
Nitropress Patient Counseling
See Literature
Nitropress Generic Name & Formulations
Legal Class
Rx
General Description
Sodium nitroprusside 25mg/mL; soln for IV infusion after dilution.
Pharmacological Class
Vasodilator.
How Supplied
Single-dose vials (2mL)—100
Manufacturer
Nitropress Indications
Indications
Immediate reduction of blood pressure during hypertensive crises.
Nitropress Dosage and Administration
Adults and Children
Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min and no more than 10 minutes. Titrate infusion rate (see literature).
Nitropress Contraindications
Contraindications
Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute CHF associated with reduced peripheral vascular resistance.
Nitropress Boxed Warnings
Boxed Warning
Not suitable for direct injection. Excessive hypotension. Cyanide toxicity.
Nitropress Warnings/Precautions
Warnings/Precautions
Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); monitor acid-base disturbances and venous oxygen concentration. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Poor surgical risk. Hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nitropress Pharmacokinetics
See Literature
Nitropress Interactions
Interactions
Hypotensive effect potentiated by ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.
Nitropress Adverse Reactions
Adverse Reactions
Excessive hypotension, cyanide toxicity, methemoglobinemia, abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitch, nausea, palpitations, restlessness, rash, hypothyroidism, ileus, flushing, infusion site reactions.
Nitropress Clinical Trials
See Literature
Nitropress Note
Not Applicable
Nitropress Patient Counseling
See Literature
