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Avalide Generic Name & Formulations
Legal Class
Rx
General Description
Irbesartan, hydrochlorothiazide; 150mg/12.5mg, 300mg/12.5mg; tabs.
Pharmacological Class
Angiotensin II receptor blocker (ARB) + thiazide diuretic.
How Supplied
Tabs—30
Manufacturer
Generic Availability
YES
Avalide Indications
Indications
Hypertension.
Avalide Dosage and Administration
Adult
Take once daily. Not controlled on monotherapy: initially 150/12.5mg, titrate to 300/12.5mg then 300/25mg if needed. Initial therapy: start at 150/12.5mg for 1–2 weeks, then titrate as needed up to max 300mg/25mg. May be substituted for titrated components. Severe renal impairment (CrCl ≤30mL/min): not recommended.
Children
Not established.
Avalide Contraindications
Contraindications
Anuria. Sulfonamide allergy. Concomitant aliskiren in patients with diabetes.
Avalide Boxed Warnings
Boxed Warning
Fetal toxicity.
Avalide Warnings/Precautions
Warnings/Precautions
Fetal toxicity may develop; discontinue if pregnancy is detected. Intravascular volume- or sodium-depletion. Correct hypovolemia before starting therapy. Hepatic impairment. Severe CHF. Severe renal disease. Renal artery stenosis. Asthma. Postsympathectomy. SLE. Gout. Acute angle-closure glaucoma. Elevated IOP. Acute myopia. Choroidal effusions. Monitor renal function and electrolytes periodically. Elderly. Neonates. Pregnancy: avoid. Nursing mothers: not recommended.
Avalide Pharmacokinetics
See Literature
Avalide Interactions
Interactions
See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. Orthostatic hypotension with alcohol, other CNS depressants. Hypokalemia with corticosteroids, ACTH. Potentiates other antihypertensives. May potentiate muscle relaxants (eg, curare derivatives). May be antagonized by, and renal toxicity potentiated by NSAIDs, including COX-2 inhibitors; monitor. Antagonizes norepinephrine. Adjust antihyperglycemics. Separate dosing by ≥4hrs before or 4–6hrs after cholestyramine or colestipol resins. May increase lithium toxicity. Risk of hyponatremia with carbamazepine (monitor). May interfere with parathyroid tests.
Avalide Adverse Reactions
Adverse Reactions
Dizziness, fatigue, musculoskeletal pain, GI upset; renal dysfunction, electrolyte and metabolic disturbances; HCTZ: increased risk for non-melanoma skin cancer.
Avalide Clinical Trials
See Literature
Avalide Note
Not Applicable
Avalide Patient Counseling
See Literature
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