Singulair

— THERAPEUTIC CATEGORIES —
  • Allergies
  • Asthma/COPD

Singulair Generic Name & Formulations

General Description

Montelukast (as sodium) 10mg; tabs.

Pharmacological Class

Leukotriene receptor antagonist.

How Supplied

Tabs—30, 90; Chew tabs, Oral granules—30

Manufacturer

Generic Availability

YES

Singulair Indications

Indications

To relieve symptoms of seasonal allergic rhinitis (for patients ≥2yrs) and perennial allergic rhinitis (for patients ≥6 months). Reserve use for those who have an inadequate response or intolerance to alternative therapies due to benefits may not outweigh the risk of neuropsychiatric symptoms (see full labeling).

Singulair Dosage and Administration

Adults and Children

Take granules by mouth within 15mins of opening packet; may dissolve in 5mL of cold or room temperature baby formula or breast milk, or mix in spoonful of soft applesauce, carrots, rice, or ice cream. <6mos w/perennial allergic rhinitis or <2yrs w/seasonal allergic rhinitis: not established. 6–23mos: one 4mg granule packet. 2–5yrs: one 4mg chew tab or granule packet. 6–14yrs: one 5mg chew tab. ≥15yrs: one 10mg tab. For all: take once daily.

Singulair Contraindications

Not Applicable

Singulair Boxed Warnings

Boxed Warning

Serious neuropsychiatric events.

Singulair Warnings/Precautions

Warnings/Precautions

Risk of serious neuropsychiatric (NP) events; monitor and discontinue if changes in behavior, new NP symptoms, or suicidal thoughts occur. In asthma or EIB: consider benefits vs risks prior to prescribing. Not for reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Avoid abrupt substitution with inhaled or oral steroids. Aspirin sensitivity. Eosinophilic conditions. Chew tabs: Phenylketonuria. Pregnancy. Nursing mothers.

Singulair Pharmacokinetics

See Literature

Singulair Interactions

Interactions

Monitor with potent CYP450 inducers (eg, phenobarbital, rifampin).

Singulair Adverse Reactions

Adverse Reactions

Upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis.

Singulair Clinical Trials

See Literature

Singulair Note

Not Applicable

Singulair Patient Counseling

See Literature

Singulair Generic Name & Formulations

General Description

Montelukast (as sodium) 10mg; tabs.

Pharmacological Class

Leukotriene receptor antagonist.

How Supplied

Tabs—30, 90; Chew tabs, Oral granules—30

Manufacturer

Generic Availability

YES

Singulair Indications

Indications

Prophylaxis and chronic treatment of asthma (for patients ≥12 months old). Prevention of exercise-induced bronchoconstriction (EIB) (for patients ≥6yrs old).

Limitations of Use

Not for the treatment of an acute asthma attack.

Singulair Dosage and Administration

Adults and Children

Take granules by mouth within 15mins of opening packet; may dissolve in 5mL of cold or room temperature baby formula or breast milk, or mix in spoonful of soft applesauce, carrots, rice, or ice cream. <12mos w/asthma or <6yrs w/EIB: not established. 12–23mos: one 4mg granule packet. 2–5yrs: one 4mg chew tab or granule packet. 6–14yrs: one 5mg chew tab. ≥15yrs: one 10mg tab. For asthma: take once daily in the PM. For EIB: Take at least 2hrs before exercise (max 1 dose/day). Do not take an additional dose within 24hrs of a previous dose or if already taking a daily dose for another indication (including chronic asthma).

Singulair Contraindications

Not Applicable

Singulair Boxed Warnings

Boxed Warning

Serious neuropsychiatric events.

Singulair Warnings/Precautions

Warnings/Precautions

Risk of serious neuropsychiatric (NP) events; monitor and discontinue if changes in behavior, new NP symptoms, or suicidal thoughts occur. In asthma or EIB: consider benefits vs risks prior to prescribing. Not for reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Avoid abrupt substitution with inhaled or oral steroids. Aspirin sensitivity. Eosinophilic conditions. Chew tabs: Phenylketonuria. Pregnancy. Nursing mothers.

Singulair Pharmacokinetics

See Literature

Singulair Interactions

Interactions

Monitor with potent CYP450 inducers (eg, phenobarbital, rifampin).

Singulair Adverse Reactions

Adverse Reactions

Upper respiratory infection, fever, headache, pharyngitis, cough, abdominal pain, diarrhea, otitis media, influenza, rhinorrhea, sinusitis.

Singulair Clinical Trials

See Literature

Singulair Note

Not Applicable

Singulair Patient Counseling

See Literature